Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28519331 | 0.91 | RIPK1 (0.50) | RIPK1PDE5AJAK2NTRK1GPR119 | |
| SCHEMBL21093668 | 0.89 | RIPK1 (0.50) | RIPK1PDE5AJAK2NTRK1GPR119 | |
| SCHEMBL31479247 | 0.89 | RIPK1 (0.50) | RIPK1PDE5AJAK2NTRK1GPR119 | |
| SCHEMBL28520937 | 0.89 | FFAR2 (0.40) | RIPK1KDM4EFFAR2 | |
| SCHEMBL28534291 | 0.88 | GPR119 (0.44) | GPR119MAOBMAOAGRM5 | |
| SCHEMBL28520946 | 0.87 | FFAR2 (0.45) | RIPK1PDE5AMAOBMAOAGRM5 | |
| SCHEMBL21094084 | 0.86 | FFAR2 (0.42) | RIPK1GPR119FFAR2 | |
| SCHEMBL28534271 | 0.86 | ABCB1 (0.44) | RIPK1GPR119FFAR2 | |
| SCHEMBL2584143 | 0.84 | RIPK1 (0.46) | RIPK1PDE5AJAK2NTRK1GPR119 | |
| SCHEMBL20835548 | 0.83 | RIPK1 (0.45) | RIPK1PDE5AKDM4EALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109476639-B | Pyrrolidine derivatives | 橘生药品工业股份有限公司 | 2021-02-26 | — | — | CN | disclosed |