Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 2/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13513684 | 0.80 | CCR1 (0.54) | MAPTNR1H4KEAP1NFE2L2KMT2A | |
| SCHEMBL2850859 | 0.79 | KEAP1 (0.51) | MAPTNR1H4KEAP1NFE2L2KMT2A | |
| SCHEMBL2852325 | 0.79 | KEAP1 (0.51) | MAPTNR1H4KEAP1NFE2L2KMT2A | |
| SCHEMBL2857470 | 0.78 | MAPT (0.46) | MAPTKEAP1NFE2L2KMT2AMEN1 | |
| SCHEMBL14258152 | 0.78 | KEAP1 (0.48) | MAPTNR1H4KEAP1NFE2L2KMT2A | |
| SCHEMBL2858034 | 0.77 | BRAF (0.43) | MAPTNR1H4LMNABRAFCCR1 | |
| SCHEMBL2858036 | 0.77 | BRAF (0.44) | MAPTNR1H4LMNABRAFMALT1 | |
| SCHEMBL2857207 | 0.75 | MAPT (0.43) | MAPTKEAP1NFE2L2LMNAKDM4E | |
| SCHEMBL2852818 | 0.75 | NPC1 (0.50) | MAPTNR1H4KMT2ABRAFCCR1 | |
| SCHEMBL2854223 | 0.75 | MAPT (0.43) | MAPTKEAP1NFE2L2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |