Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | CCR1 | P32246 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | MST1R | Q04912 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4882364 | 0.88 | KDM4E (0.48) | BRAFMALT1KDM4EALDH1A1NR1H4 | |
| SCHEMBL2858036 | 0.81 | BRAF (0.44) | BRAFMALT1KDM4EALDH1A1NR1H4 | |
| SCHEMBL13513708 | 0.78 | KDM4E (0.53) | BRAFMALT1KDM4EALDH1A1MAPT | |
| SCHEMBL2852818 | 0.78 | NPC1 (0.50) | BRAFMALT1KDM4EALDH1A1NR1H4 | |
| SCHEMBL14539344 | 0.77 | KDM4E (0.52) | BRAFMALT1KDM4EALDH1A1NR1H4 | |
| SCHEMBL2852028 | 0.77 | MAPT (0.46) | BRAFMALT1KDM4EALDH1A1NR1H4 | |
| SCHEMBL2857034 | 0.76 | KDM4E (0.62) | BRAFKDM4EALDH1A1NR1H4MAPT | |
| SCHEMBL2850892 | 0.76 | NR1H4 (0.53) | BRAFMALT1KDM4EALDH1A1NR1H4 | |
| SCHEMBL14258157 | 0.75 | KEAP1 (0.50) | BRAFMALT1KDM4EALDH1A1NR1H4 | |
| SCHEMBL13513684 | 0.75 | CCR1 (0.54) | BRAFMALT1KDM4EALDH1A1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |