Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 9/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4882354 | 0.88 | NPC1 (0.49) | BRAFMAPTNPC1RAB9ANR1H4 | |
| SCHEMBL2850892 | 0.82 | NR1H4 (0.53) | BRAFMAPTNPC1RAB9ANR1H4 | |
| SCHEMBL2858034 | 0.81 | BRAF (0.43) | BRAFMAPTTP53THRBNR1H4 | |
| SCHEMBL14539344 | 0.81 | KDM4E (0.52) | BRAFMAPTNR1H4MALT1KDM4E | |
| SCHEMBL2853811 | 0.80 | SMN1; SMN2 (0.60) | BRAFMAPTNPC1RAB9ATP53 | |
| SCHEMBL2852818 | 0.80 | NPC1 (0.50) | BRAFMAPTNPC1RAB9ATP53 | |
| SCHEMBL14539343 | 0.79 | NR1H4 (0.47) | BRAFMAPTNR1H4MALT1KDM4E | |
| SCHEMBL13513708 | 0.78 | KDM4E (0.53) | BRAFMAPTMALT1KDM4EALDH1A1 | |
| SCHEMBL2852028 | 0.77 | MAPT (0.46) | BRAFMAPTTP53THRBNR1H4 | |
| SCHEMBL2857034 | 0.77 | KDM4E (0.62) | BRAFMAPTNPC1RAB9ANR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |