Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 5/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.55 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.50 |
| ▸ | LSS | P48449 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2855676 | 0.89 | CCR1 (0.63) | CCR1HPGDMAPTNPSR1NPC1 | |
| SCHEMBL2857166 | 0.89 | HPGD (0.80) | CCR1HPGDMAPTNPC1PKM | |
| SCHEMBL2857860 | 0.87 | CCR1 (0.75) | CCR1HPGDMAPTNPSR1ALDH1A1 | |
| SCHEMBL2850617 | 0.86 | HPGD (0.84) | CCR1HPGDNPSR1NPC1PKM | |
| SCHEMBL2859678 | 0.85 | CCR1 (0.55) | CCR1ABCB1LMNAMAPTNR3C1 | |
| SCHEMBL2854531 | 0.83 | LMNA (0.52) | CCR1ABCB1LMNAMAPTNPC1 | |
| SCHEMBL2856505 | 0.83 | TP53 (0.59) | CCR1HPGDLMNAMAPTNPSR1 | |
| SCHEMBL2850603 | 0.80 | HPGD (0.73) | CCR1HPGDMAPTNPSR1NPC1 | |
| SCHEMBL2859795 | 0.79 | NPC1 (0.59) | CCR1HPGDLMNAMAPTNPSR1 | |
| SCHEMBL2851942 | 0.78 | NPC1 (0.64) | HPGDMAPTNPC1PKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |