Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.80 |
| ▸ | NPC1 | O15118 | 4/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.61 |
| ▸ | RELA | Q04206 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 3/20 | 0.60 |
| ▸ | CCR1 | P32246 | 6/20 | 0.57 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | PDE2A | O00408 | 1/20 | 0.53 |
| ▸ | EED | O75530 | 1/20 | 0.53 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.53 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.53 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.53 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856089 | 0.89 | HPGD (1.00) | HPGDNPC1RAB9APKMNFKB1 | |
| SCHEMBL2852082 | 0.89 | CCR1 (0.72) | HPGDNPC1RAB9APKMMAPT | |
| SCHEMBL2855676 | 0.89 | CCR1 (0.63) | HPGDNPC1RAB9APKMMAPT | |
| SCHEMBL2851942 | 0.89 | NPC1 (0.64) | HPGDNPC1RAB9APKMMAPT | |
| SCHEMBL2854347 | 0.86 | HPGD (0.84) | HPGDNPC1RAB9AMAPTTP53 | |
| SCHEMBL2856505 | 0.85 | TP53 (0.59) | HPGDNPC1RAB9APKMMAPT | |
| SCHEMBL2859795 | 0.85 | NPC1 (0.59) | HPGDNPC1RAB9APKMMAPT | |
| SCHEMBL2850316 | 0.85 | TP53 (0.59) | HPGDMAPTSMN1; SMN2TP53CCR1 | |
| SCHEMBL2857152 | 0.82 | NPC1 (0.91) | HPGDNPC1RAB9APKMMAPT | |
| SCHEMBL2860234 | 0.82 | HPGD (0.54) | HPGDNPC1RAB9APKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |