Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.48 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PRNP | P04156 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28518164 | 0.82 | TSHR (0.52) | LMNAMAPTALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL28513461 | 0.79 | MAPK1 (0.53) | LMNAMAPTALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL30160665 | 0.79 | MAPK1 (0.53) | LMNAMAPTALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL28512866 | 0.79 | TSHR (0.46) | LMNASMN1; SMN2MEN1KMT2AHTT | |
| SCHEMBL28516403 | 0.79 | GAA (0.50) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL28513463 | 0.76 | MAT2A (0.47) | LMNAALOX5ALDH1A1NPSR1KDM4E | |
| SCHEMBL11813837 | 0.75 | GRIK1 (0.56) | LMNAMAPTALDH1A1SMN1; SMN2GRIK1 | |
| SCHEMBL28512956 | 0.75 | CYP19A1 (0.53) | LMNAMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL5442868 | 0.74 | CYP11B2 (0.52) | LMNAMAPTALDH1A1SMN1; SMN2GRIK1 | |
| SCHEMBL28593371 | 0.73 | KDM4E (0.47) | MAPTALDH1A1SMN1; SMN2HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110105359-B | Method for synthesizing indene spiro isoindole [2,1-b ] isoquinoline triketone compound | 河南师范大学 | 2021-08-03 | — | — | CN | disclosed |
| CN-108997339-B | Method for synthesizing isoindole [2,1-b ] isoquinoline-7-carboxylic ester compound | 河南师范大学 | 2021-01-29 | — | — | CN | disclosed |