Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 10/20 | 0.50 |
| ▸ | ESR1 | P03372 | 11/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2299673 | 0.86 | KIF11 (0.55) | KIF11ESR2ESR1HSD17B1HSD17B2 | |
| SCHEMBL31348999 | 0.83 | ESR2 (0.50) | KIF11ESR2ESR1MEN1KMT2A | |
| SCHEMBL257619 | 0.82 | KIF11 (0.49) | KIF11ESR2HSD17B1HSD17B2 | |
| SCHEMBL177370 | 0.81 | — | — | |
| SCHEMBL29692338 | 0.81 | — | — | |
| SCHEMBL1042606 | 0.80 | ALDH1A1 (0.54) | KIF11ESR2ESR1MEN1KMT2A | |
| SCHEMBL30285974 | 0.80 | ALDH1A1 (0.54) | KIF11ESR2ESR1MEN1KMT2A | |
| SCHEMBL1513602 | 0.79 | KIF11 (0.61) | KIF11ESR2ESR1MEN1KMT2A | |
| SCHEMBL27982534 | 0.79 | ESR1 (0.55) | KIF11ESR2ESR1MEN1KMT2A | |
| SCHEMBL2741575 | 0.78 | KIF11 (0.46) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265692-B1 | THIOPHENE DERIVATIVES, AND LC MEDIA CONTAINING THE SAME | MERCK PATENT GMBH (DE) | 2012-07-04 | — | — | EP | disclosed |
| US-20120001123-A1 | THIOPHENE DERIVATIVES, AND LC MEDIA COMPRISING SAME | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-01-05 | — | — | US | disclosed |
| US-20110049427-A1 | Thiophene derivatives, and LC media containing same | MERCK PATENT GESELLSCHAFT (DE) | 2011-03-03 | — | — | US | disclosed |
| WO-2010099853-A1 | THIOPHENE DERIVATES AND LIQUID CRYSTAL MEDIA COMPRISING THE SAME | MERCK PATENT GMBH (DE) | 2010-09-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120001123-A1 | THIOPHENE DERIVATIVES, AND LC MEDIA COMPRISING SAME | TEC, TPMT, TST | KIF11 1267/4885ESR2 3634/4885ESR1 2491/4885 |
| US-20110049427-A1 | Thiophene derivatives, and LC media containing same | TPMT, TEC, LCT | KIF11 1344/4885ESR2 3647/4885ESR1 2560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.