Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 3/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.48 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10208772 | 0.83 | ADRB1 (0.46) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL24774596 | 0.81 | HTR1A (0.43) | PDK2PDK4MEN1KMT2AHTR1A | |
| SCHEMBL3435705 | 0.79 | NR1I2 (0.44) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL3436617 | 0.79 | ADRB1 (0.45) | PDK2PDK4CCNE2CDK4CCND1 | |
| SCHEMBL3173745 | 0.78 | ADRB1 (0.45) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL27676113 | 0.78 | HTR1A (0.49) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL31058296 | 0.78 | AR (0.43) | PDK2PDK4CCNE2CDK4CCND1 | |
| SCHEMBL21778414 | 0.77 | ITGB2 (0.46) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL19937825 | 0.76 | FFAR1 (0.45) | PDK2PDK4CCNE2CDK4CCND1 | |
| SCHEMBL6937201 | 0.76 | NOS1 (0.40) | MEN1KMT2AHTR1ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117430601-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-112437772-A | Bcl-2 inhibitors | 百济神州有限公司 | 2021-03-02 | — | — | CN | disclosed |