Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | MAT2A | P31153 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | MST1R | Q04912 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854798 | 0.89 | MEN1 (0.47) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL2852244 | 0.84 | MAPT (0.48) | MAPTMEN1KMT2APOLBORAI1 | |
| SCHEMBL2854162 | 0.84 | NPC1 (0.58) | NPC1RAB9AHTTMALT1 | |
| SCHEMBL2853154 | 0.83 | MAPT (0.44) | MAPTMEN1KMT2APOLBORAI1 | |
| SCHEMBL2850258 | 0.83 | MAPT (0.51) | MAPTMEN1KMT2ANPSR1KDM4E | |
| SCHEMBL2858436 | 0.82 | MEN1 (0.46) | NPC1RAB9AHTTMAPTMEN1 | |
| SCHEMBL2850858 | 0.82 | KDR (0.48) | RAB9AHTTMAPTMEN1KMT2A | |
| SCHEMBL2860975 | 0.82 | MAPT (0.49) | NPC1MAPTMEN1KMT2APOLB | |
| SCHEMBL2848317 | 0.82 | MAPT (0.46) | NPC1MAPTMEN1KMT2APOLB | |
| SCHEMBL2854221 | 0.81 | MAPT (0.51) | MAPTMEN1KMT2ANPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |