Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | MALT1 | Q9UDY8 | 19/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2852783 | 0.89 | TMPRSS4 (0.57) | MALT1 | |
| SCHEMBL2852636 | 0.84 | NPC1 (0.46) | NPC1HTTRAB9AMALT1 | |
| SCHEMBL2856075 | 0.81 | NAMPT (0.56) | RAB9AMALT1 | |
| SCHEMBL2852805 | 0.81 | KDR (0.56) | HTTMALT1 | |
| SCHEMBL2857034 | 0.81 | KDM4E (0.62) | NPC1RAB9A | |
| SCHEMBL2855512 | 0.80 | MALT1 (0.55) | MALT1 | |
| SCHEMBL2852818 | 0.79 | NPC1 (0.50) | NPC1RAB9AMALT1 | |
| SCHEMBL13513708 | 0.79 | KDM4E (0.53) | MALT1 | |
| SCHEMBL2850282 | 0.79 | KDM4E (0.58) | NPC1RAB9A | |
| SCHEMBL2850859 | 0.79 | KEAP1 (0.51) | MALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |