Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 19/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3672721 | 0.91 | RIPK1 (0.54) | RIPK1DAOCCNB2CDK1CCNB1 | |
| SCHEMBL14838870 | 0.72 | CCNB2 (0.65) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL31704117 | 0.72 | CCNB2 (0.65) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| Phosphoric Acid SCHEMBL29264269 | 0.71 | DAO (0.50) | RIPK1DAO | |
| Phosphoric Acid SCHEMBL31544068 | 0.71 | DAO (0.50) | RIPK1DAO | |
| SCHEMBL451378 | 0.70 | RIPK1 (0.50) | RIPK1DAOCCNB2CDK1CCNB1 | |
| SCHEMBL31374627 | 0.70 | RIPK1 (0.58) | RIPK1DAOCCNB2CDK1CCNB1 | |
| Triphosphate SCHEMBL28137708 | 0.70 | DAO (0.46) | RIPK1DAOCCNB2CDK1CCNB1 | |
| SCHEMBL31537211 | 0.68 | GSK3B (0.58) | — | |
| SCHEMBL6016016 | 0.68 | GSK3B (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112500408-A | Pyronaridine phosphate compound and preparation method thereof | 湖北美林药业有限公司 | 2021-03-16 | — | — | CN | disclosed |