SCHEMBL451378

SCHEMBL451378

c1cnc2[nH]c3cnnc-3cc2c1

nearest known ligand 0.50

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
RIPK1 Q13546 16/20 0.50
CCNB2 O95067 1/20 0.47
CDK1 P06493 1/20 0.47
CCNB1 P14635 1/20 0.47
CCNB3 Q8WWL7 1/20 0.47
CCNE1 P24864 1/20 0.46
CDK2 P24941 1/20 0.46
DAO P14920 1/20 0.45
CLK2 P49760 2/20 0.43
CLK3 P49761 2/20 0.43
DYRK1A Q13627 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3672721 0.77 RIPK1 (0.54) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL5669939 0.74 RAB9A (0.48)
SCHEMBL31374627 0.73 RIPK1 (0.58) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL14838870 0.72 CCNB2 (0.65) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL31704117 0.72 CCNB2 (0.65) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL1780991 0.71 CYP19A1 (0.66) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL1538594 0.71 DAO (0.46) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL2595303 0.71 DAO (0.53) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL1778505 0.70 RIPK1 (0.74) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL20670460 0.70 RIPK1 (0.54) RIPK1CCNB2CDK1CCNB1CCNB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 232 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10071156-B2 Aqueous gel formulations containing immune response modifiers 3M INNOVATIVE PROPERTIES COMPANY (US) 2018-09-11 US claimed
US-20160101173-A1 AQUEOUS GEL FORMULATIONS CONTAINING IMMUNE RESPONSE MODIFIERS 3M INNOVATIVE PROPERTIES CO (US) 2016-04-14 US claimed
US-9248127-B2 Aqueous gel formulations containing immune response modifiers 3M INNOVATIVE PROPERTIES COMPANY (US) 2016-02-02 US claimed
US-20090163532-A1 Aqueous Gel Formulations Containing Immune Response Modifiers COLEY PHARMACEUTICAL GROUP, INC. (US) 2009-06-25 US claimed
EP-1844201-A2 AQUEOUS GEL FORMULATIONS CONTAINING IMMUNE RESPONSE MODIFIERS 3M INNOVATIVE PROPERTIES COMPANY (US) 2007-10-17 EP claimed
WO-2006084251-A2 AQUEOUS GEL FORMULATIONS CONTAINING IMMUNE REPONSE MODIFIERS COLEY PHARMACEUTICAL GROUP, INC. (US) 2006-08-10 WO claimed
EP-0526840-B1 Condensed naphthyridine derivatives KYOWA HAKKO KOGYO KK (JP) 1997-10-22 EP claimed
US-5281610-A Pyrazolonaphthyridine pharmaceuticals KYOWA HAKKO KOGYO CO., LTD. (JP) 1994-01-25 US claimed
EP-0526840-A1 Condensed naphthyridine derivatives KYOWA HAKKO KOGYO CO., LTD. (JP) 1993-02-10 EP claimed
US-20240173390-A1 PEPTIDE VACCINE FORMULATIONS AND USE THEREOF FOR INDUCING AN IMMUNE RESPONSE THE U.S.A, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-05-30 US disclosed
WO-2024092028-A2 COMBINATION TREATMENT REGIMES FOR TREATING CANCER VACCITECH NORTH AMERICA, INC. (US) 2024-05-02 WO disclosed
WO-2024092030-A1 SELF-ASSEMBLING NANOPARTICLES VACCITECH NORTH AMERICA, INC. (US) 2024-05-02 WO disclosed
US-11938177-B2 Peptide vaccine formulations and use thereof for inducing an immune response THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-03-26 US disclosed
EP-4294431-A1 SELF-ASSEMBLING NANOPARTICLES BASED ON AMPHIPHILIC PEPTIDES Vaccitech North America, Inc. (US) 2023-12-27 EP disclosed
WO-2005079195-A2 PYRAZOLOPYRIDINES AND ANALOGS THEREOF 3M INNOVATIVE PROPERTIES COMPANY (US) 2005-09-01 WO disclosed
EP-0526840-B1 Condensed naphthyridine derivatives KYOWA HAKKO KOGYO KK (JP) 1997-10-22 EP disclosed
US-5281610-A Pyrazolonaphthyridine pharmaceuticals KYOWA HAKKO KOGYO CO., LTD. (JP) 1994-01-25 US disclosed
US-5281610-A Pyrazolonaphthyridine pharmaceuticals KYOWA HAKKO KOGYO CO., LTD. (JP) 1994-01-25 US disclosed
EP-0526840-A1 Condensed naphthyridine derivatives KYOWA HAKKO KOGYO CO., LTD. (JP) 1993-02-10 EP disclosed
EP-0526840-A1 Condensed naphthyridine derivatives KYOWA HAKKO KOGYO CO., LTD. (JP) 1993-02-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240173390-A1 PEPTIDE VACCINE FORMULATIONS AND USE THEREOF FOR INDUCING AN IMMUNE RESPONSE NGLY1, MYD88, SPPL2B RIPK1 1275/4885CCNB2 2387/4885CDK1 4054/4885
US-10071156-B2 Aqueous gel formulations containing immune response modifiers IFNG, ICOS, IL4 RIPK1 1412/4885CCNB2 1438/4885CDK1 562/4885
US-11938177-B2 Peptide vaccine formulations and use thereof for inducing an immune response NGLY1, MYD88, SPPL2B RIPK1 1275/4885CCNB2 2387/4885CDK1 4054/4885
US-20090163532-A1 Aqueous Gel Formulations Containing Immune Response Modifiers IFNG, ICOS, IL4 RIPK1 1412/4885CCNB2 1438/4885CDK1 562/4885
US-20160101173-A1 AQUEOUS GEL FORMULATIONS CONTAINING IMMUNE RESPONSE MODIFIERS IFNG, ICOS, IL4 RIPK1 1412/4885CCNB2 1438/4885CDK1 562/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.