Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.44 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2852839 | 0.91 | SLC7A5 (0.40) | KDM4EALDH1A1ERCC1ERCC4SLC7A5 | |
| SCHEMBL2860110 | 0.89 | KDM4E (0.47) | KDM4EALDH1A1GAAKMT2AMAPT | |
| SCHEMBL2854509 | 0.89 | KDM4E (0.50) | KDM4EALDH1A1GAAMAPTPOLB | |
| SCHEMBL2857230 | 0.89 | KDM4E (0.44) | KDM4EALDH1A1GAAMAPTPOLB | |
| SCHEMBL2860826 | 0.88 | KDM4E (0.43) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2859644 | 0.88 | ALDH1A1 (0.43) | KDM4EALDH1A1GAAKMT2AMAPT | |
| SCHEMBL2856562 | 0.87 | MAPT (0.48) | KDM4EALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL2850868 | 0.87 | ALDH1A1 (0.51) | ALDH1A1KMT2AMAPTSMN1; SMN2HPGD | |
| SCHEMBL2853061 | 0.86 | KDM4E (0.44) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2863198 | 0.86 | CCR1 (0.50) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |