Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SPR | P35270 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2857238 | 0.92 | CCR1 (0.43) | MAPTSPRCCR1LMNANPSR1 | |
| SCHEMBL2854509 | 0.91 | KDM4E (0.50) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2853061 | 0.90 | KDM4E (0.44) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2863198 | 0.90 | CCR1 (0.50) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2852221 | 0.90 | ALDH1A1 (0.46) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2860110 | 0.89 | KDM4E (0.47) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2852955 | 0.89 | KDM4E (0.44) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2854586 | 0.88 | ALDH1A1 (0.47) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2852941 | 0.86 | POLB (0.44) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2859644 | 0.86 | ALDH1A1 (0.43) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |