Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 9/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CASR | P41180 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28529959 | 0.88 | CSF1R (0.56) | CSF1RALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL28538513 | 0.86 | CSF1R (0.58) | CSF1RALDH1A1PDE4AKCNH2TP53 | |
| SCHEMBL3293704 | 0.86 | CSF1R (0.53) | CSF1RALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL28527127 | 0.84 | CSF1R (0.59) | CSF1RTSHRPDE4AKCNH2 | |
| SCHEMBL3291981 | 0.84 | CSF1R (0.58) | CSF1RPDE4AKCNH2 | |
| SCHEMBL28908007 | 0.83 | CSF1R (0.59) | CSF1RPDE4AKCNH2 | |
| SCHEMBL28527136 | 0.83 | CSF1R (0.56) | CSF1RALDH1A1MEN1KMT2A | |
| SCHEMBL3291712 | 0.83 | CSF1R (0.54) | CSF1RALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL28526527 | 0.82 | NPSR1 (0.60) | CSF1RALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL28909928 | 0.82 | CSF1R (0.53) | CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111848613-B | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2021-09-24 | — | — | CN | claimed |
| CN-111848613-A | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2020-10-30 | — | — | CN | claimed |
| CN-111848613-B | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2021-09-24 | — | — | CN | disclosed |
| CN-111848613-A | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2020-10-30 | — | — | CN | disclosed |