Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 11/20 | 0.58 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | VCP | P55072 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28526524 | 0.88 | CSF1R (0.57) | CSF1R | |
| SCHEMBL28530641 | 0.86 | CSF1R (0.62) | CSF1RPDE4AKCNH2TP53MAPT | |
| SCHEMBL28527127 | 0.85 | CSF1R (0.59) | CSF1RPDE4AKCNH2FGFR1RAB9A | |
| SCHEMBL28540961 | 0.83 | CSF1R (0.54) | CSF1R | |
| SCHEMBL28908007 | 0.82 | CSF1R (0.59) | CSF1RPDE4AKCNH2 | |
| SCHEMBL28526527 | 0.81 | NPSR1 (0.60) | CSF1RTP53MAPTALDH1A1RAB9A | |
| SCHEMBL28527136 | 0.80 | CSF1R (0.56) | CSF1RKDM5BALDH1A1 | |
| SCHEMBL28522950 | 0.79 | CSF1R (0.53) | CSF1RMAPTALDH1A1 | |
| SCHEMBL3290606 | 0.78 | CSF1R (0.58) | CSF1RPDE4AKCNH2TP53MAPT | |
| SCHEMBL3293704 | 0.76 | CSF1R (0.53) | CSF1RPDE4AKCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111848613-B | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2021-09-24 | — | — | CN | claimed |
| CN-111848613-A | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2020-10-30 | — | — | CN | claimed |
| CN-111848613-B | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2021-09-24 | — | — | CN | disclosed |
| CN-111848613-A | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2020-10-30 | — | — | CN | disclosed |