Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28536975 | 0.93 | MAPT (0.49) | NOTUMENPP2POLBHTR1AMAPT | |
| SCHEMBL28532287 | 0.83 | CHRNB2 (0.53) | NOTUMPOLBMAPTALDH1A1SERPINE1 | |
| SCHEMBL6714666 | 0.83 | MAPT (0.53) | POLBHTR1AMAPTALDH1A1LMNA | |
| SCHEMBL30474477 | 0.82 | MAPT (0.55) | POLBMAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL28537487 | 0.82 | MAPT (0.55) | POLBMAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL28539978 | 0.82 | ACACB (0.41) | POLBMAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL30474517 | 0.82 | HPGD (0.51) | NOTUMPOLBMAPTALDH1A1LMNA | |
| SCHEMBL28547071 | 0.82 | ALDH1A1 (0.45) | MAPTALDH1A1LMNASLC6A9SLC6A5 | |
| SCHEMBL28525978 | 0.82 | HPGD (0.51) | NOTUMPOLBMAPTALDH1A1LMNA | |
| SCHEMBL21619788 | 0.80 | NOTUM (0.51) | NOTUMMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112513021-B | ROR gamma antagonist and application thereof in medicines | 广东东阳光药业有限公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-112513021-A | ROR gamma antagonist and application thereof in medicine | 广东东阳光药业有限公司 | 2021-03-16 | — | — | CN | disclosed |