Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 8/20 | 0.43 |
| ▸ | PGR | P06401 | 7/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | LIPC | P11150 | 1/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18305166 | 0.84 | NR3C2 (0.45) | NR3C2PGRNR3C1ARHTR1A | |
| SCHEMBL28907820 | 0.82 | KDM4E (0.45) | NR3C2PGRNR3C1TRPV1 | |
| SCHEMBL28533641 | 0.81 | CREBBP (0.35) | BRD4CREBBPDRD2LIPCLIPG | |
| SCHEMBL13343850 | 0.72 | BRD4 (0.54) | NR3C2PGRNR3C1HTR1ABRD4 | |
| SCHEMBL28525830 | 0.71 | KDM4E (0.43) | CRBN | |
| SCHEMBL4265400 | 0.70 | NR3C2 (0.53) | NR3C2PGRNR3C1HTR1AHTR1D | |
| SCHEMBL8195296 | 0.69 | BRD4 (0.43) | NR3C2PGRNR3C1HTR1AHTR1D | |
| SCHEMBL4262107 | 0.68 | NR3C2 (0.51) | NR3C2PGRNR3C1HTR1AHTR1D | |
| SCHEMBL14079839 | 0.66 | ADRB2 (0.39) | NR3C2PGRNR3C1HTR1AHTR1D | |
| SCHEMBL4289205 | 0.66 | NR3C2 (0.45) | NR3C2PGRNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107873031-B | Benzoxazinone derivatives and analogs thereof as modulators of TNF activity | UCB生物制药私人有限公司 | 2021-03-12 | — | — | CN | disclosed |