Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAOK1 | Q7L7X3 | 8/20 | 0.48 |
| ▸ | TAOK3 | Q9H2K8 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.39 |
| ▸ | MDH1 | P40925 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13711650 | 0.92 | TAOK1 (0.50) | TAOK1TAOK3KDM4ECTSDBACE1 | |
| SCHEMBL2857395 | 0.91 | KDM4E (0.48) | TAOK1TAOK3KDM4ECTSDBACE1 | |
| SCHEMBL2855184 | 0.88 | KDM4E (0.46) | KDM4ECTSDBACE1ALDH1A1ACHE | |
| SCHEMBL13711749 | 0.79 | KDM4E (0.48) | KDM4ECTSDBACE1ALDH1A1 | |
| SCHEMBL2858467 | 0.77 | SSTR3 (0.48) | KDM4ECTSDBACE1ALDH1A1 | |
| SCHEMBL2858230 | 0.76 | TAOK1 (0.38) | TAOK1TAOK3CYP4A11MDH1CYP4F2 | |
| SCHEMBL5598085 | 0.76 | KDM4E (0.41) | TAOK1TAOK3KDM4ECTSDBACE1 | |
| SCHEMBL1813169 | 0.75 | CYP4A11 (0.62) | CYP4A11MDH1ALDH1A1CYP4F2 | |
| SCHEMBL2853542 | 0.74 | CYP4A11 (0.55) | CYP4A11MDH1CYP4F2 | |
| SCHEMBL27920400 | 0.71 | ACHE (0.58) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654247-B1 | ALKYNYL ARYL CARBOXAMIDES | MERCK SERONO SA (CH) | 2010-01-20 | — | — | EP | claimed |
| US-20070105913-A1 | Alkynyl aryl carboxamides | APPLIED RESEARCH SYSTEMS ARS HOLDINGS N.V. (NL) | 2007-05-10 | — | — | US | claimed |
| EP-1654247-B1 | ALKYNYL ARYL CARBOXAMIDES | MERCK SERONO SA (CH) | 2010-01-20 | — | — | EP | disclosed |
| US-7589232-B2 | Alkynyl aryl carboxamides | LABORATORIES SERONO S.A. (CH) | 2009-09-15 | — | — | US | disclosed |
| US-7589232-B2 | Alkynyl aryl carboxamides | LABORATORIES SERONO S.A. (CH) | 2009-09-15 | — | — | US | disclosed |
| US-20070105913-A1 | Alkynyl aryl carboxamides | APPLIED RESEARCH SYSTEMS ARS HOLDINGS N.V. (NL) | 2007-05-10 | — | — | US | disclosed |
| US-20070105913-A1 | Alkynyl aryl carboxamides | APPLIED RESEARCH SYSTEMS ARS HOLDINGS N.V. (NL) | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105913-A1 | Alkynyl aryl carboxamides | ECHS1, IRS1, HCCS | TAOK1 3737/4885TAOK3 3756/4885KDM4E 1973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.