Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TAOK1 | Q7L7X3 | 4/20 | 0.39 |
| ▸ | TAOK3 | Q9H2K8 | 4/20 | 0.39 |
| ▸ | PLK1 | P53350 | 4/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | PTPRO | Q16827 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5598540 | 0.87 | KDM4E (0.41) | KDM4EALDH1A1HDAC1HDAC6 | |
| SCHEMBL2857395 | 0.81 | KDM4E (0.48) | KDM4ETAOK1TAOK3CTSDBACE1 | |
| SCHEMBL2853430 | 0.76 | TAOK1 (0.48) | KDM4ETAOK1TAOK3CTSDBACE1 | |
| SCHEMBL5598402 | 0.70 | RARB (0.54) | PLK1PTPN11PTPRORARBS1PR1 | |
| SCHEMBL5598384 | 0.69 | PLK1 (0.54) | PLK1PTPN11PTPRORARB | |
| SCHEMBL13711650 | 0.67 | TAOK1 (0.50) | KDM4ETAOK1TAOK3CTSDBACE1 | |
| SCHEMBL2858924 | 0.66 | RARB (0.61) | PLK1ACACBALDH1A1RARBS1PR4 | |
| SCHEMBL5598223 | 0.66 | PLK1 (0.50) | PLK1PTPN11PTPROALDH1A1RARB | |
| SCHEMBL2851976 | 0.66 | RARB (0.52) | PLK1PTPN11PTPROALDH1A1RARB | |
| SCHEMBL1811178 | 0.65 | RARB (0.73) | PLK1PTPN11PTPROACACBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070105913-A1 | Alkynyl aryl carboxamides | APPLIED RESEARCH SYSTEMS ARS HOLDINGS N.V. (NL) | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105913-A1 | Alkynyl aryl carboxamides | ECHS1, IRS1, HCCS | KDM4E 1973/4885TAOK1 3737/4885TAOK3 3756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.