Methyl P-Toluenesulfonyl-L-Argininate

Methyl P-Toluenesulfonyl-L-Argininate

SCHEMBL2853451

COC(=O)C(CCCNC(=N)N)NS(=O)(=O)c1ccc(C)cc1

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 2/20 0.57
ITGA2B P08514 2/20 0.57
PLAU P00749 7/20 0.52
HPN P05981 7/20 0.52
BMP1 P13497 3/20 0.46
ALDH1A1 P00352 2/20 0.46
KDM4E B2RXH2 1/20 0.46
HPGD P15428 1/20 0.46
MAPT P10636 1/20 0.43
MMP2 P08253 2/20 0.43
MMP9 P14780 2/20 0.43
ADAM10 O14672 1/20 0.43
MMP12 P39900 1/20 0.43
MMP14 P50281 1/20 0.43
ADAM8 P78325 1/20 0.43
ADAM17 P78536 1/20 0.43
LMNA P02545 1/20 0.43
ALB P02768 1/20 0.43
CYP2C9 P11712 1/20 0.43
TSHR P16473 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methyl P-Toluenesulfonyl-L-Argininate SCHEMBL324561 1.00 ITGB3 (0.57) ITGB3ITGA2BPLAUHPNBMP1
Methyl P-Toluenesulfonyl-L-Argininate SCHEMBL1034821 0.99 ITGB3 (0.56) ITGB3ITGA2BPLAUHPNBMP1
Methyl P-Toluenesulfonyl-L-Argininate SCHEMBL11880215 0.99 ITGB3 (0.56) ITGB3ITGA2BPLAUHPNBMP1
SCHEMBL1839480 0.92 ITGB3 (0.56) ITGB3ITGA2BPLAUHPNALDH1A1
SCHEMBL1839478 0.92 ITGB3 (0.56) ITGB3ITGA2BPLAUHPNALDH1A1
Methoxymethane SCHEMBL8925022 0.90 ITGB3 (0.67) ITGB3ITGA2BPLAUHPNMMP2
SCHEMBL27734963 0.90 BMP1 (0.52) ITGB3ITGA2BBMP1MMP2MMP9
SCHEMBL1244355 0.90 ITGB3 (0.60) ITGB3ITGA2BPLAUHPNALDH1A1
SCHEMBL17318886 0.89 ITGB3 (0.54) ITGB3ITGA2BPLAUHPNALDH1A1
Hydrochloric Acid SCHEMBL7319933 0.88 ITGB3 (0.59) ITGB3ITGA2BPLAUHPNALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-57016698-A None JP disclosed
JP-3004790-A None JP disclosed
CN-112533597-B Method for purifying proteins and peptides 卡耐基梅隆大学 2025-02-25 CN disclosed
CN-118359709-A Antibodies that bind to human metapneumovirus fusion proteins and uses thereof 佐治亚大学研究基金会有限公司 2024-07-19 CN disclosed
CN-114174331-B Antibodies that bind to human metapneumovirus fusion proteins and uses thereof 佐治亚大学研究基金会有限公司 2024-06-04 CN disclosed
US-11655271-B2 Protein and peptide purification methods CARNEGIE MELLON UNIVERSITY (US) 2023-05-23 US disclosed
CN-115791667-A Enzyme activity detection method and system for nattokinase in dried natto 南宁学院 2023-03-14 CN disclosed
EP-3466961-B1 PROLINAMIDE DERIVATIVE AS THROMBIN INHIBITOR LI MIN (US) 2022-04-06 EP disclosed
US-20210253630-A1 Protein and Peptide Purification Methods NATIONAL SCIENCE FOUNDATION 2021-08-19 US disclosed
EP-3801485-A1 PROTEIN AND PEPTIDE PURIFICATION METHODS CARNEGIE MELLON UNIVERSITY (US) 2021-04-14 EP disclosed
US-4514416-A Amidine compound, process for producing same and anti-complement agent comprising same TORII & CO. LTD. (JP) 1985-04-30 US disclosed
US-4496584-A ANTITRYPSIN, ANTIKALLIKREIN, ANTITHROMBIN OR ANTIPLASMIN AGENT TORII & CO. LTD. (JP) 1985-01-29 US disclosed
US-4490388-A ENZYME INHIBITORS; ANTICOAGULANTS TORII & CO., LTD. (JP) 1984-12-25 US disclosed
US-4428874-A QUANTITATIVE ANALYSIS OF PROTEOLYTIC ENZYMES PENTAPHARM A.G. (CH) 1984-01-31 US disclosed
US-4327178-A Urinary kallikrein assay: specific substrates and assay method UNIVERSITY OF MIAMI (US) 1982-04-27 US disclosed
JP-S5716698-A MEASURING METHOD OF ALPHA2-PLASMIN INHIBITOR YATORON:KK 1982-01-28 JP disclosed
US-4243753-A Apparatus for enzyme detection PURDUE RESEARCH FOUNDATION (US) 1981-01-06 US disclosed
US-4234477-A DIAGNOSTIC DETERMINATION OF A HYDROLASE, CALLICREIN BAYER AKTIENGESELLSCHAFT (DE) 1980-11-18 US disclosed
US-4214093-A PROTEOLYTIC ENZYME INHIBITORS TORII & CO., LTD. (JP) 1980-07-22 US disclosed
US-4182897-A ENZYME INHIBITORS FOR PROTEOLYTIC ENZYMES TORII & CO., LTD. (JP) 1980-01-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210253630-A1 Protein and Peptide Purification Methods ANPEP, DNPEP, RNPEP ITGB3 4068/4885ITGA2B 3764/4885PLAU 140/4885
US-11655271-B2 Protein and peptide purification methods ANPEP, DNPEP, RNPEP ITGB3 4068/4885ITGA2B 3764/4885PLAU 140/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.