Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.46 |
| ▸ | QDPR | P09417 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | SNCA | P37840 | 4/20 | 0.40 |
| ▸ | GUSB | P08236 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | GRK6 | P43250 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049587 | 0.79 | ALDH1A1 (0.41) | GUSBGAAMGAMSIMGAM2 | |
| SCHEMBL4041568 | 0.76 | HSD17B1 (0.47) | GAAMGAMSIMGAM2MAPT | |
| SCHEMBL6002502 | 0.74 | AHR (0.46) | GAAMAPTIDO1KDM4EALDH1A1 | |
| SCHEMBL28536156 | 0.71 | NISCH (0.47) | MAPTALDH1A1 | |
| SCHEMBL28535250 | 0.70 | KDM4E (0.50) | ALOX5GUSBGAAKDM4EALDH1A1 | |
| SCHEMBL29142674 | 0.70 | NPC1 (0.50) | APPGUSBGAA | |
| SCHEMBL29142667 | 0.70 | BRD4 (0.43) | APPKDM4EALDH1A1POLBHPGD | |
| SCHEMBL403894 | 0.70 | MTOR (0.43) | GAAMAPTIDO1KDM4EALDH1A1 | |
| SCHEMBL10057826 | 0.70 | APP (0.56) | APPQDPRALOX5SNCAGUSB | |
| SCHEMBL2650383 | 0.69 | IDO1 (0.49) | GAAMGAMSIMGAM2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112512522-A | Compounds for the treatment of triple negative breast and ovarian cancer | 田纳西大学研究基金会 | 2021-03-16 | — | — | CN | disclosed |
| CN-112437664-A | Compounds for the treatment of pancreatic cancer | 田纳西大学研究基金会 | 2021-03-02 | — | — | CN | disclosed |