Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MALT1 | Q9UDY8 | 14/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850157 | 0.90 | KDM4E (0.47) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2860428 | 0.86 | KDM4E (0.52) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2855560 | 0.84 | ALDH1A1 (0.49) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2855566 | 0.84 | MALT1 (0.44) | KDM4EALDH1A1MAPTMALT1 | |
| SCHEMBL2854514 | 0.81 | CNR2 (0.35) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2294498 | 0.75 | MAPT (0.66) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL31007090 | 0.73 | MAPT (0.49) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL30147290 | 0.73 | MAPT (0.49) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2855927 | 0.73 | MALT1 (0.57) | MALT1 | |
| SCHEMBL2860499 | 0.72 | RAB9A (0.35) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |