Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CCR1 | P32246 | 5/20 | 0.46 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.42 |
| ▸ | GPR6 | P46095 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2855560 | 0.87 | ALDH1A1 (0.49) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2854040 | 0.86 | KDM4E (0.48) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2850157 | 0.85 | KDM4E (0.47) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2858119 | 0.84 | MAPT (0.43) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2862815 | 0.83 | DRD2 (0.41) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2855566 | 0.83 | MALT1 (0.44) | KDM4EALDH1A1MAPTMALT1 | |
| SCHEMBL2853091 | 0.82 | MAPT (0.49) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2857034 | 0.77 | KDM4E (0.62) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2860432 | 0.77 | KCNMA1 (0.51) | KDM4EALDH1A1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL2852931 | 0.77 | KDM4E (0.57) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |