SCHEMBL2854049

SCHEMBL2854049

COc1ccc2[nH]nc(C(=O)O[C@H]3CN4CCC3CC4)c2c1

nearest known ligand 0.52

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 14/20 0.52
RBP4 P02753 1/20 0.47
HTR3E A5X5Y0 1/20 0.47
HTR3B O95264 1/20 0.47
CHRNB2 P17787 1/20 0.47
CHRNA7 P36544 1/20 0.47
CHRNA4 P43681 1/20 0.47
HTR3A P46098 1/20 0.47
HTR3D Q70Z44 1/20 0.47
HTR3C Q8WXA8 1/20 0.47
PRKAG1 P54619 1/20 0.45
PRKAA1 Q13131 1/20 0.45
PRKAB1 Q9Y478 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2856114 1.00 GSK3B (0.52) GSK3BRBP4HTR3EHTR3BCHRNB2
SCHEMBL2854175 1.00 GSK3B (0.52) GSK3BRBP4HTR3EHTR3BCHRNB2
SCHEMBL13528904 1.00 GSK3B (0.52) GSK3BRBP4HTR3EHTR3BCHRNB2
Formic Acid SCHEMBL2857648 0.96 GSK3B (0.48) GSK3BRBP4HTR3EHTR3BCHRNB2
Formic Acid SCHEMBL2861542 0.96 GSK3B (0.48) GSK3BRBP4HTR3EHTR3BCHRNB2
Formic Acid SCHEMBL2859293 0.96 GSK3B (0.48) GSK3BRBP4HTR3EHTR3BCHRNB2
SCHEMBL2851300 0.92 CHRNA7 (0.47) GSK3BHTR3EHTR3BCHRNB2CHRNA7
SCHEMBL2851299 0.92 CHRNA7 (0.47) GSK3BHTR3EHTR3BCHRNB2CHRNA7
SCHEMBL2855680 0.92 CHRNA7 (0.47) GSK3BHTR3EHTR3BCHRNB2CHRNA7
Formic Acid SCHEMBL2864650 0.88 CHRNA7 (0.44) GSK3BHTR3EHTR3BCHRNB2CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1828179-B1 NICOTINIC ALPHA-7 RECEPTOR LIGANDS AGAINST CNS-RELATED DISEASES MEMORY PHARM CORP (US) 2010-01-20 EP claimed
US-7625924-B2 Nicotinic alpha-7 receptor ligands and preparation and uses thereof MEMORY PHARMACEUTICALS CORPORATION (US) 2009-12-01 US claimed
US-20060167039-A1 Nicotinic alpha-7 receptor ligands and preparation and uses thereof MEMORY PHARMACEUTICALS CORPORATION 2006-07-27 US claimed
CN-122080557-A Room-temperature self-repairing electromagnetic shielding hydrogel composite material and preparation method thereof 2026-05-26 CN disclosed
WO-2023023867-A1 COMPOUNDS FOR REDUCING CHOLESTEROL AND TREATING LIVER AND KIDNEY DISEASE MCMASTER UNIVERSITY (CA) 2023-03-02 WO disclosed
US-20220396581-A1 COMPOUNDS FOR THE TREATMENT OF PARAMYXOVIRUS VIRAL INFECTIONS Janssen Biopharma, Inc. (US) 2022-12-15 US disclosed
CN-114867811-A Adhesive composition 住友化学株式会社 2022-08-05 CN disclosed
CN-114671978-A Composition for encapsulating organic light emitting diode and organic light emitting diode display 三星SDI株式会社 2022-06-28 CN disclosed
CN-110872365-B Composition for encapsulating organic light emitting diode and organic light emitting diode display 三星SDI株式会社 2022-04-15 CN disclosed
US-11014935-B2 Compounds for the treatment of paramyxovirus viral infections Janssen Biopharma, Inc. (US) 2021-05-25 US disclosed
US-20200200945-A1 POLYCARBONATE RESIN LENS AND POLYCARBONATE RESIN COMPOSITION MITSUI CHEMICALS, INC. (JP) 2020-06-25 US disclosed
US-20090215828-A1 Substituted indole derivatives GRUNENTHAL GMBH (DE) 2009-08-27 US disclosed
US-20080064037-A1 RNA-SELECTIVE PROBES FOR LIVE CELL IMAGING OF NUCLEAR STRUCTURE AND FUNCTION NEW YORK UNIVERSITY (US) 2008-03-13 US disclosed
US-20080064037-A1 RNA-SELECTIVE PROBES FOR LIVE CELL IMAGING OF NUCLEAR STRUCTURE AND FUNCTION NEW YORK UNIVERSITY (US) 2008-03-13 US disclosed
EP-1828179-A2 NICOTINIC ALPHA-7 RECEPTOR LIGANDS AND PREPARATION AND USES THEREOF Memory Pharmaceutical Corporation (US) 2007-09-05 EP disclosed
US-7202265-B2 Indolinone combinatorial libraries and related products and methods for the treatment of disease SUGEN, INC. (US) 2007-04-10 US disclosed
US-7202265-B2 Indolinone combinatorial libraries and related products and methods for the treatment of disease SUGEN, INC. (US) 2007-04-10 US disclosed
US-20070010559-A1 Indole derivatives for use as chemical uncoupler NOVO NORDISK A/S (DK) 2007-01-11 US disclosed
US-20060167039-A1 Nicotinic alpha-7 receptor ligands and preparation and uses thereof MEMORY PHARMACEUTICALS CORPORATION 2006-07-27 US disclosed
WO-2006069097-A2 NICOTINIC ALPHA-7 RECEPTOR LIGANDS AND PREPARATION AND USES THEREOF MEMORY PHARMACEUTICALS CORPORATION (US) 2006-06-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080064037-A1 RNA-SELECTIVE PROBES FOR LIVE CELL IMAGING OF NUCLEAR STRUCTURE AND FUNCTION SNRPE, HNRNPUL2, EFTUD2 GSK3B 4376/4885RBP4 1557/4885HTR3E 3418/4885
US-20090215828-A1 Substituted indole derivatives IDO1, IDO2, TPH1 GSK3B 76/4885RBP4 4458/4885HTR3E 13/4885
US-20220396581-A1 COMPOUNDS FOR THE TREATMENT OF PARAMYXOVIRUS VIRAL INFECTIONS MAVS, SARS1, ZC3HAV1 GSK3B 2317/4885RBP4 389/4885HTR3E 3052/4885
US-11014935-B2 Compounds for the treatment of paramyxovirus viral infections MAVS, SARS1, ZC3HAV1 GSK3B 2317/4885RBP4 389/4885HTR3E 3052/4885
US-20060167039-A1 Nicotinic alpha-7 receptor ligands and preparation and uses thereof CHRNA7, CHRNA5, CHRNA6 GSK3B 1971/4885RBP4 3263/4885HTR3E 628/4885
US-20070010559-A1 Indole derivatives for use as chemical uncoupler GPR119, IDO2, IDO1 GSK3B 2512/4885RBP4 2082/4885HTR3E 32/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.