Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bisphenol A. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.67 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | TYR | P14679 | 2/20 | 0.67 |
| ▸ | ESRRG | P62508 | 2/20 | 0.67 |
| ▸ | AR | P10275 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.67 |
| ▸ | HTR6 | P50406 | 1/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | CA12 | O43570 | 1/20 | 0.67 |
| ▸ | CA1 | P00915 | 1/20 | 0.67 |
| ▸ | CA2 | P00918 | 1/20 | 0.67 |
| ▸ | CA3 | P07451 | 1/20 | 0.67 |
| ▸ | DRD1 | P21728 | 1/20 | 0.67 |
| ▸ | CA4 | P22748 | 1/20 | 0.67 |
| ▸ | CA6 | P23280 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4348947 | 1.00 | ESR1 (0.67) | ESR1ESR2CYP3A4TSHRTYR | |
| Bisphenol A SCHEMBL11427584 | 0.98 | ESR1 (0.64) | ESR1ESR2CYP3A4TSHRTYR | |
| Bisphenol A SCHEMBL5935233 | 0.92 | ESR1 (0.70) | ESR1ESR2CYP3A4TSHRTYR | |
| SCHEMBL1635858 | 0.91 | SRD5A2 (0.65) | ESR1ESR2CYP3A4TSHRTYR | |
| SCHEMBL71433 | 0.91 | SRD5A2 (0.65) | ESR1ESR2CYP3A4TSHRTYR | |
| Bisphenol A SCHEMBL6933678 | 0.91 | ESR1 (0.55) | ESR1ESR2CYP3A4TSHRTYR | |
| Bisphenol A SCHEMBL1683933 | 0.91 | ESR1 (0.55) | ESR1ESR2CYP3A4TSHRTYR | |
| Benzoic Acid SCHEMBL27569004 | 0.90 | ESR1 (0.74) | ESR1ESR2CYP3A4TSHRTYR | |
| Bisphenol A SCHEMBL17889902 | 0.90 | ESR1 (0.64) | ESR1ESR2CYP3A4TSHRTYR | |
| Bisphenol A SCHEMBL30693768 | 0.89 | ESR1 (0.61) | ESR1ESR2CYP3A4TSHRTYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747302-A2 | REPAIR AND OPTIMIZATION OF NANOCOMPOSITE MATERIALS | Nanocore ApS (DK) | 2026-05-27 | — | — | EP | claimed |
| WO-2025062180-A1 | SYSTEMS, METHODS, AND COMPOSITIONS FOR UPCYCLING POLYESTERS | 9449710 CANADA INC. (CA) | 2025-03-27 | — | — | WO | claimed |
| CN-109390711-B | Cold sealing terminal of anaerobic sealant | 苏州晗普新材料科技有限公司 | 2024-05-14 | — | — | CN | claimed |
| US-20230257601-A1 | RUBBER SURFACE COATING SYSTEM | NO MORE SMELLS LIMITED (GB) | 2023-08-17 | — | — | US | claimed |
| US-4129594-A | Process for the manufacture of aromatic dicarboxylic acid chlorides | ALLIED CHEMICAL CORPORATION (US) | 1978-12-12 | — | — | US | claimed |
| EP-4747302-A2 | REPAIR AND OPTIMIZATION OF NANOCOMPOSITE MATERIALS | Nanocore ApS (DK) | 2026-05-27 | — | — | EP | disclosed |
| US-12578006-B2 | Barbed wire repair apparatuses and methods for making and using same | HARRIS NORMAN (US) | 2026-03-17 | — | — | US | disclosed |
| US-20250361448-A1 | PROCESS AND APPARATUS FOR CONTINUOUS THERMAL DECOMPOSITION OF PLASTIC WASTE | RANDOW GREGG (US) | 2025-11-27 | — | — | US | disclosed |
| US-12404437-B2 | Fiber reinforced flexible foams | L&P PROPERTY MANAGEMENT COMPANY (US) | 2025-09-02 | — | — | US | disclosed |
| US-12405547-B2 | Toner comprising reactive charge control agent | XEROX CORPORATION (US) | 2025-09-02 | — | — | US | disclosed |
| US-20250243068-A1 | COMPOSITE MATERIALS AND PROCESSES FOR THE PREPARATION THEREOF | NANOCORE APS (DK) | 2025-07-31 | — | — | US | disclosed |
| US-12371538-B2 | Method of preparing polymer particles and polymer particles prepared thereby | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2025-07-29 | — | — | US | disclosed |
| US-20030171528-A1 | Wholly aromatic polyester carbonate and process for production of same | TEIJIN LIMITED | 2003-09-11 | — | — | US | disclosed |
| EP-1336633-A1 | AROMATIC POLYESTER CARBONATE AND METHOD FOR PRODUCTION THEREOF | TEIJIN LIMITED (JP) | 2003-08-20 | — | — | EP | disclosed |
| US-6087007-A | Heat-Resistant optical plastic laminated sheet and its producing method | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 2000-07-11 | — | — | US | disclosed |
| US-4788283-A | LIGHT STABILIZERS FOR POLYMERRS | CIBA-GEIGY CORPORATION (US) | 1988-11-29 | — | — | US | disclosed |
| EP-0213466-A2 | Method for preparing sulfonated polycarbonates and their use as flame retardants | GENERAL ELECTRIC COMPANY (US) | 1987-03-11 | — | — | EP | disclosed |
| US-4280951-A | ESTERIFIED PHOSPHORUS-CONTAINING PRODUCTS WITH ACRYLIC ACIDS | SANKO KAIHATSU KAGAKU KENKYUSHO (JP) | 1981-07-28 | — | — | US | disclosed |
| US-4219635-A | CONTROLLING TEMPERATURE DURING COPOLYMERIZATION | ALLIED CHEMICAL CORPORATION (US) | 1980-08-26 | — | — | US | disclosed |
| US-4129594-A | Process for the manufacture of aromatic dicarboxylic acid chlorides | ALLIED CHEMICAL CORPORATION (US) | 1978-12-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12578006-B2 | Barbed wire repair apparatuses and methods for making and using same | MRE11, WHR1, BROX | ESR1 1832/4885ESR2 1918/4885CYP3A4 4775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.