Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | CCR1 | P32246 | 7/20 | 0.71 |
| ▸ | EED | O75530 | 1/20 | 0.57 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.57 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.57 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.57 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TACR1 | P25103 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850143 | 0.92 | CCR1 (0.85) | HPGDCCR1NPSR1KDM4ENPC1 | |
| SCHEMBL2854060 | 0.88 | KDM4E (0.65) | HPGDCCR1KDM4EMAPTPOLB | |
| SCHEMBL2856222 | 0.85 | MAPT (0.67) | HPGDCCR1MAPTPOLB | |
| SCHEMBL2856089 | 0.85 | HPGD (1.00) | HPGDCCR1EEDRBBP4SUZ12 | |
| SCHEMBL5678637 | 0.83 | CCR1 (1.00) | HPGDCCR1NPSR1KDM4EHSP90AA1 | |
| SCHEMBL2855614 | 0.82 | CCR1 (0.50) | HPGDCCR1NPSR1KDM4ETACR1 | |
| SCHEMBL2850396 | 0.82 | KDM4E (0.60) | HPGDCCR1KDM4EMAPTPOLB | |
| SCHEMBL2854061 | 0.82 | HPGD (0.84) | HPGDCCR1EEDRBBP4SUZ12 | |
| SCHEMBL25781800 | 0.80 | CCR1 (0.54) | CCR1TACR1 | |
| SCHEMBL2857071 | 0.80 | CCR1 (0.57) | CCR1KDM4ETACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |