Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.61 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28542435 | 0.92 | HRH3 (0.55) | HRH3HRH4CCNCCDK8BTK | |
| SCHEMBL16685016 | 0.86 | LSS (0.47) | HRH3 | |
| SCHEMBL4336110 | 0.85 | TRPV1 (0.48) | HRH3 | |
| SCHEMBL28555574 | 0.81 | HRH3 (0.57) | HRH3HRH4PDE4DROCK2CCNC | |
| SCHEMBL16684964 | 0.80 | GPR119 (0.53) | HRH3 | |
| SCHEMBL16620603 | 0.78 | TRPV1 (0.43) | HRH3 | |
| SCHEMBL29177368 | 0.78 | HRH3 (0.61) | HRH3 | |
| SCHEMBL1775467 | 0.77 | LMNA (0.64) | HRH4 | |
| SCHEMBL3784623 | 0.76 | HRH3 (1.00) | HRH3HRH4 | |
| SCHEMBL17626780 | 0.76 | HRH3 (0.81) | HRH3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108135175-B | Bicyclic compounds and their use for inhibition of SUV39H2 | 肿瘤疗法科学股份有限公司 | 2021-04-06 | — | — | CN | disclosed |