Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27738442 | 0.85 | LMNA (0.53) | LMNAMAPTCYP1A2CYP2D6KMT2A | |
| SCHEMBL26695699 | 0.81 | LMNA (0.48) | LMNAMAPTCYP1A2KMT2ASMN1; SMN2 | |
| SCHEMBL29283185 | 0.80 | LMNA (0.41) | LMNA | |
| SCHEMBL21858189 | 0.79 | LMNA (0.61) | LMNAMAPTCYP1A2CYP2D6KMT2A | |
| SCHEMBL28543561 | 0.77 | HRH3 (0.61) | HRH4 | |
| SCHEMBL5149830 | 0.77 | LMNA (0.58) | LMNAMAPTCYP1A2CYP2D6KMT2A | |
| SCHEMBL5153329 | 0.76 | LMNA (0.67) | LMNAMAPTCYP1A2CYP2D6KMT2A | |
| SCHEMBL16701665 | 0.76 | LMNA (0.63) | LMNAMAPTCYP1A2CYP2D6KMT2A | |
| SCHEMBL21777093 | 0.75 | CYP1A2 (0.40) | LMNAMAPTCYP1A2CYP2D6SMN1; SMN2 | |
| SCHEMBL26695651 | 0.74 | SPHK1 (0.42) | KMT2ASMN1; SMN2MEN1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943628-B2 | Pyrimidine derivatives | PFIZER LIMITED (GB) | 2011-05-17 | — | — | US | disclosed |
| CN-101277951-A | 2-aminopyrimidine derivatives as modulators of the histamine H4 receptor activity | PALAU PHARMA SA (ES) | 2008-10-01 | — | — | CN | disclosed |