Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1B | P00325 | 2/20 | 0.64 |
| ▸ | ADH1C | P00326 | 2/20 | 0.64 |
| ▸ | ADH1A | P07327 | 2/20 | 0.64 |
| ▸ | ADH7 | P40394 | 2/20 | 0.64 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.64 |
| ▸ | ADH4 | P08319 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | RARB | P10826 | 8/20 | 0.54 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | RARA | P10276 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MTOR | P42345 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.53 |
| ▸ | NAAA | Q02083 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL986326 | 0.95 | NAAA (0.59) | ADH1BADH1CADH1AADH7EPHX1 | |
| Terephthalic Acid SCHEMBL23270887 | 0.85 | TP53 (0.59) | TP53TSHRRARBPLA2G4BMEN1 | |
| Terephthalic Acid SCHEMBL28502502 | 0.84 | TP53 (0.71) | TP53TSHRRARBPLA2G4BMEN1 | |
| Terephthalic Acid SCHEMBL28142960 | 0.84 | TP53 (0.71) | TP53TSHRRARBPLA2G4BMEN1 | |
| Dodecane SCHEMBL9354416 | 0.84 | TP53 (0.71) | TP53TSHRRARBPLA2G4BMEN1 | |
| Tetradecane SCHEMBL30605685 | 0.84 | TP53 (0.71) | TP53TSHRRARBPLA2G4BMEN1 | |
| 4-Methylbenzoic Acid SCHEMBL31121225 | 0.83 | L3MBTL1 (0.64) | TP53TSHRRARBPLA2G4BMEN1 | |
| Terephthalic Acid SCHEMBL1884274 | 0.82 | RARB (0.68) | TP53TSHRRARBPLA2G4BMEN1 | |
| Terephthalic Acid SCHEMBL2944670 | 0.82 | RARB (0.68) | TP53TSHRRARBPLA2G4BMEN1 | |
| Benzoic Acid SCHEMBL32671576 | 0.82 | NAAA (0.65) | EPHX1TP53TSHRRARBPLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112646150-B | Boiling-resistant high-leveling polyester resin for HAA (haha) cured powder coating and preparation method thereof | 浙江光华科技股份有限公司 | 2022-07-05 | — | — | CN | claimed |
| CN-112646150-A | Boiling-resistant high-leveling polyester resin for HAA (haha) cured powder coating and preparation method thereof | 浙江光华科技股份有限公司 | 2021-04-13 | — | — | CN | claimed |
| CN-112646150-B | Boiling-resistant high-leveling polyester resin for HAA (haha) cured powder coating and preparation method thereof | 浙江光华科技股份有限公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-112646150-B | Boiling-resistant high-leveling polyester resin for HAA (haha) cured powder coating and preparation method thereof | 浙江光华科技股份有限公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-112646150-A | Boiling-resistant high-leveling polyester resin for HAA (haha) cured powder coating and preparation method thereof | 浙江光华科技股份有限公司 | 2021-04-13 | — | — | CN | disclosed |
| CN-112646150-A | Boiling-resistant high-leveling polyester resin for HAA (haha) cured powder coating and preparation method thereof | 浙江光华科技股份有限公司 | 2021-04-13 | — | — | CN | disclosed |