Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2858151 | 0.87 | KMT2A (0.52) | LMNAHPGDHTTALDH1A1RAB9A | |
| SCHEMBL2851650 | 0.86 | TSHR (0.63) | LMNAHPGDHTTALDH1A1KMT2A | |
| SCHEMBL2857253 | 0.84 | ALDH1A1 (0.47) | LMNAHPGDHTTALDH1A1KMT2A | |
| SCHEMBL23135876 | 0.81 | LMNA (0.68) | LMNAHPGDHTTALDH1A1RAB9A | |
| SCHEMBL2852749 | 0.78 | HPGD (0.43) | LMNAHPGDPOLBTDP1 | |
| SCHEMBL14816841 | 0.76 | HPGD (1.00) | LMNAHPGDHTTALDH1A1KMT2A | |
| SCHEMBL2856257 | 0.76 | NPC1 (0.50) | HTTALDH1A1RAB9ATP53KMT2A | |
| SCHEMBL2861183 | 0.76 | TP53 (0.47) | LMNAHPGDALDH1A1TP53 | |
| SCHEMBL28313230 | 0.76 | HPGD (0.81) | LMNAHPGDHTTALDH1A1RAB9A | |
| SCHEMBL27892112 | 0.76 | HTT (1.00) | LMNAHPGDHTTALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963277-B1 | FLUORINATED COMPOUNDS | NPS PHARMA INC (US) | 2010-01-20 | — | — | EP | claimed |
| EP-1963277-B1 | FLUORINATED COMPOUNDS | NPS PHARMA INC (US) | 2010-01-20 | — | — | EP | disclosed |
| WO-2007076306-A1 | FLUORINATED COMPOUNDS | NPS PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |