Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854437 | 0.86 | LMNA (0.64) | GAAKMT2ALMNAALDH1A1HTT | |
| SCHEMBL2858151 | 0.85 | KMT2A (0.52) | RECQLGAAKMT2AMEN1LMNA | |
| SCHEMBL2856257 | 0.83 | NPC1 (0.50) | KMT2AALDH1A1HTTL3MBTL1 | |
| SCHEMBL2861183 | 0.83 | TP53 (0.47) | TSHRRECQLEPHX2LMNAALDH1A1 | |
| SCHEMBL2857253 | 0.80 | ALDH1A1 (0.47) | GAAKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL2852749 | 0.80 | HPGD (0.43) | TSHRRECQLLMNAHPGD | |
| SCHEMBL15850415 | 0.79 | TSHR (0.69) | TSHRRECQLGAAKMT2AMEN1 | |
| SCHEMBL8533502 | 0.79 | TSHR (0.69) | TSHRRECQLGAAKMT2AMEN1 | |
| SCHEMBL2849993 | 0.77 | USP2 (0.64) | TSHRRECQLGAAKMT2AMEN1 | |
| SCHEMBL10967899 | 0.76 | GAA (0.72) | TSHRRECQLGAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963277-B1 | FLUORINATED COMPOUNDS | NPS PHARMA INC (US) | 2010-01-20 | — | — | EP | claimed |
| US-7902401-B2 | Fluorinated compounds | NPS PHARMACEUTICALS, INC. (US) | 2011-03-08 | — | — | US | disclosed |
| EP-1963277-B1 | FLUORINATED COMPOUNDS | NPS PHARMA INC (US) | 2010-01-20 | — | — | EP | disclosed |