Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856257 | 0.84 | NPC1 (0.50) | TP53ALDH1A1KDM4E | |
| SCHEMBL2858151 | 0.83 | KMT2A (0.52) | HPGDALDH1A1KDM4ERECQLLMNA | |
| SCHEMBL14679455 | 0.83 | MMP13 (0.55) | TP53MMP13EPHX2HPGDALDH1A1 | |
| SCHEMBL2851650 | 0.83 | TSHR (0.63) | EPHX2HPGDALDH1A1TSHRRECQL | |
| SCHEMBL24324228 | 0.79 | CYP3A4 (0.60) | TP53MMP13EPHX2HPGDALDH1A1 | |
| SCHEMBL14679423 | 0.79 | MMP13 (0.58) | TP53MMP13EPHX2HPGDALDH1A1 | |
| SCHEMBL14679157 | 0.79 | KDM4E (0.57) | TP53MMP13HPGDALDH1A1KDM4E | |
| SCHEMBL2857253 | 0.78 | ALDH1A1 (0.47) | HPGDALDH1A1KDM4ELMNA | |
| SCHEMBL2861180 | 0.78 | MMP13 (0.46) | TP53MMP13HPGDALDH1A1KDM4E | |
| SCHEMBL1434371 | 0.77 | SMN1; SMN2 (0.58) | TP53MMP13HPGDALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963277-B1 | FLUORINATED COMPOUNDS | NPS PHARMA INC (US) | 2010-01-20 | — | — | EP | claimed |
| EP-1963277-B1 | FLUORINATED COMPOUNDS | NPS PHARMA INC (US) | 2010-01-20 | — | — | EP | disclosed |