Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | CCR1 | P32246 | 6/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856202 | 0.83 | CCR1 (0.55) | MAPTCCR1ALDH1A1CYP3A4PDE2A | |
| SCHEMBL2850360 | 0.82 | MAPT (0.61) | MAPTGAAMAPK14ALDH1A1MAPK1 | |
| SCHEMBL2852031 | 0.76 | PDE2A (0.47) | ALDH1A1LMNAPDE2A | |
| SCHEMBL2079637 | 0.75 | NR4A3 (0.59) | MAPTGAAMAPK14ALDH1A1MAPK1 | |
| SCHEMBL1403169 | 0.75 | MAPT (0.54) | MAPTGAAMAPK14ALDH1A1MAPK1 | |
| SCHEMBL12264440 | 0.73 | CCR1 (0.59) | MAPTCCR1ALDH1A1CYP3A4PDE2A | |
| SCHEMBL2402871 | 0.73 | CCR1 (0.59) | MAPTCCR1ALDH1A1CYP3A4PDE2A | |
| SCHEMBL5927588 | 0.73 | ALDH1A1 (0.44) | MAPTGAACCR1MAPK14ALDH1A1 | |
| SCHEMBL1403425 | 0.73 | HSD11B1 (0.56) | MAPTGAAMAPK14ALDH1A1MAPK1 | |
| SCHEMBL2854493 | 0.73 | GPR142 (0.56) | MAPTGAAMAPK14ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |