Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | NT5E | P21589 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854490 | 0.82 | MAPT (0.50) | MAPTALDH1A1MAPK14GAAMAPK1 | |
| SCHEMBL2852439 | 0.82 | MAPT (0.56) | MAPTALDH1A1MAPK14GAALMNA | |
| SCHEMBL2856945 | 0.81 | ALDH1A1 (0.81) | MAPTALDH1A1MAPK14GAAMAPK1 | |
| SCHEMBL2854295 | 0.81 | MAPK14 (0.68) | MAPTALDH1A1MAPK14GAAMAPK1 | |
| SCHEMBL1403169 | 0.80 | MAPT (0.54) | MAPTALDH1A1MAPK14GAAMAPK1 | |
| SCHEMBL2079637 | 0.80 | NR4A3 (0.59) | MAPTALDH1A1MAPK14GAAMAPK1 | |
| SCHEMBL2856280 | 0.78 | MAPK14 (0.55) | MAPTALDH1A1MAPK14GAAMAPK1 | |
| SCHEMBL2855512 | 0.77 | MALT1 (0.55) | MAPTALDH1A1POLBNR3C1NT5E | |
| SCHEMBL1403425 | 0.77 | HSD11B1 (0.56) | MAPTALDH1A1MAPK14GAAMAPK1 | |
| SCHEMBL2854493 | 0.77 | GPR142 (0.56) | MAPTALDH1A1MAPK14GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |