Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | BTK | Q06187 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2855060 | 0.91 | ALDH1A1 (0.43) | ALDH1A1PAK1ACKR3BTKMEN1 | |
| SCHEMBL973611 | 0.86 | LMNA (0.37) | CTSBCTSSCTSKKCNH2LMNA | |
| SCHEMBL2853786 | 0.86 | LMNA (0.38) | CTSBCTSSCTSKKCNH2ALDH1A1 | |
| SCHEMBL2858190 | 0.84 | MEN1 (0.38) | CTSBCTSSCTSKKCNH2ALDH1A1 | |
| SCHEMBL974388 | 0.83 | DRD2 (0.43) | CTSBCTSSCTSKKCNH2ALDH1A1 | |
| SCHEMBL2861257 | 0.83 | SMN1; SMN2 (0.37) | ALDH1A1PAK1ACKR3BTKMEN1 | |
| SCHEMBL972936 | 0.81 | LMNA (0.39) | CTSBCTSSCTSKKCNH2ALDH1A1 | |
| SCHEMBL974674 | 0.80 | BTK (0.39) | CTSBCTSSCTSKKCNH2LMNA | |
| SCHEMBL973921 | 0.80 | SMN1; SMN2 (0.38) | CTSBCTSSCTSKKCNH2ALDH1A1 | |
| SCHEMBL973133 | 0.80 | LMNA (0.38) | CTSBCTSSCTSKKCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968957-B1 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2010-01-20 | — | — | EP | claimed |