Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2855060 | 0.86 | ALDH1A1 (0.43) | SMN1; SMN2BTKPAK1POLBKDM4E | |
| SCHEMBL974372 | 0.85 | SMPD3 (0.36) | BTKSMPD3DRD4ACKR3NPC1 | |
| SCHEMBL2856121 | 0.85 | PAK1 (0.40) | SMN1; SMN2BTKPAK1POLBACKR3 | |
| SCHEMBL2863170 | 0.84 | PPARG (0.36) | SMN1; SMN2BTKPAK1CCNE1CDK2 | |
| SCHEMBL2854730 | 0.83 | CTSB (0.37) | SMN1; SMN2BTKPAK1POLBACKR3 | |
| SCHEMBL973992 | 0.83 | BTK (0.45) | BTKSMPD3DRD4NPC1RAB9A | |
| SCHEMBL2858043 | 0.83 | CCNE1 (0.40) | SMN1; SMN2BTKCCNE1CDK2NPC1 | |
| SCHEMBL974402 | 0.80 | BTK (0.37) | BTKCCNE1CDK2SMPD3DRD4 | |
| SCHEMBL974290 | 0.79 | BTK (0.38) | SMN1; SMN2BTKSMPD3ACKR3NPC1 | |
| SCHEMBL973986 | 0.79 | SMPD3 (0.41) | BTKSMPD3DRD4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968957-B1 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2010-01-20 | — | — | EP | claimed |