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Tryptophan

Tryptophan

SCHEMBL29220361

CC(C)C[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O.N[C@@H](Cc1ccccc1)C(=O)O

nearest known ligand 0.47

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Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ KISS1R Q969F8 15/20 0.47
▸ GHSR Q92847 2/20 0.46
▸ NPY2R P49146 1/20 0.46
▸ NPBWR1 P48145 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tryptophan SCHEMBL28979632 0.94 KDM4E (0.45) KISS1RGHSRNPBWR1
Dl-Tryptophan SCHEMBL29078368 0.90 NPBWR1 (0.50) KISS1RNPBWR1
Dl-Tryptophan SCHEMBL28880639 0.89 KDM4E (0.45) KISS1RGHSR
Dl-Tryptophan SCHEMBL27944528 0.89 KDM4E (0.45) KISS1R
Dl-Tryptophan SCHEMBL29062048 0.89 OPRM1 (0.47) KISS1RNPY2R
Dl-Tryptophan SCHEMBL28548179 0.88 KDM4E (0.46) KISS1RGHSRNPY2R
Tryptophan SCHEMBL27434560 0.88 GLP1R (0.49) GHSRNPY2R
Tryptophan SCHEMBL27389650 0.88 TUBB4A (0.44) GHSRNPY2RNPBWR1
Dl-Tryptophan SCHEMBL28838628 0.87 IL1RN (0.48) KISS1RNPY2R
Dl-Tryptophan SCHEMBL28632232 0.87 KDM4E (0.53) GHSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118240015-A Targeting polypeptide and radioactive tracer for brain glioma 中国科学院近代物理研究所 2024-06-25 — — CN claimed
CN-118108796-A Targeted treatment of glioma211At-labeled polypeptide and preparation method thereof 中国科学院近代物理研究所 2024-05-31 — — CN claimed
CN-118240015-A Targeting polypeptide and radioactive tracer for brain glioma 中国科学院近代物理研究所 2024-06-25 — — CN disclosed
CN-118240015-A Targeting polypeptide and radioactive tracer for brain glioma 中国科学院近代物理研究所 2024-06-25 — — CN disclosed
CN-118108796-A Targeted treatment of glioma211At-labeled polypeptide and preparation method thereof 中国科学院近代物理研究所 2024-05-31 — — CN disclosed
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