Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRB | P28702 | 9/20 | 0.64 |
| ▸ | RXRA | P19793 | 9/20 | 0.64 |
| ▸ | RXRG | P48443 | 6/20 | 0.64 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.54 |
| ▸ | CD69 | Q07108 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | PTGIR | P43119 | 5/20 | 0.48 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.48 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.48 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3479749 | 0.98 | RXRB (0.66) | RXRBRXRARXRGMRGPRX4CD69 | |
| SCHEMBL13768229 | 0.84 | RXRA (0.57) | RXRBRXRARXRGMRGPRX4KDM4E | |
| SCHEMBL28550871 | 0.82 | MRGPRX4 (0.60) | RXRBRXRARXRGMRGPRX4KDM4E | |
| SCHEMBL8546134 | 0.82 | RXRA (0.54) | RXRBRXRARXRGMRGPRX4KDM4E | |
| SCHEMBL19582253 | 0.82 | RXRB (0.48) | RXRBRXRARXRGCD69KDM4E | |
| SCHEMBL19599364 | 0.81 | ADRA2A (0.60) | RXRBRXRARXRG | |
| SCHEMBL2876699 | 0.80 | RXRA (0.54) | RXRBRXRARXRGMRGPRX4KDM4E | |
| SCHEMBL1839684 | 0.79 | MRGPRX4 (0.63) | RXRBRXRARXRGMRGPRX4KDM4E | |
| SCHEMBL5508804 | 0.79 | RXRA (0.54) | RXRBRXRARXRGMRGPRX4KDM4E | |
| SCHEMBL3478697 | 0.79 | RXRA (0.51) | RXRBRXRARXRGMRGPRX4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112638870-A | Process for the preparation of methyl 6- (2, 4-dichlorophenyl) -5- [4- [ (3S) -1- (3-fluoropropyl) pyrrolidin-3-yl ] oxyphenyl ] -8, 9-dihydro-7H-benzo [7] annulene-2-carboxylate | 赛诺菲 | 2021-04-09 | — | — | CN | disclosed |
| CN-112638869-A | Salt of methyl 6- (2, 4-dichlorophenyl) -5- [4- [ (3S) -1- (3-fluoropropyl) pyrrolidin-3-yl ] oxyphenyl ] -8, 9-dihydro-7H-benzo [7] annulene-2-carboxylate and process for preparing same | 赛诺菲 | 2021-04-09 | — | — | CN | disclosed |