Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.57 |
| ▸ | HTT | P42858 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | PKM | P14618 | 4/20 | 0.57 |
| ▸ | CASP6 | P55212 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | IDO1 | P14902 | 3/20 | 0.48 |
| ▸ | CTSB | P07858 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5822770 | 0.81 | PDE10A (0.45) | MAPTKDM4ETDP1HTTSMN1; SMN2 | |
| SCHEMBL8566513 | 0.76 | CASP6 (0.44) | MAPTKDM4ETDP1HTTSMN1; SMN2 | |
| SCHEMBL5257685 | 0.74 | KDM4E (0.50) | MAPTKDM4ETDP1HTTSMN1; SMN2 | |
| SCHEMBL2167844 | 0.73 | MAPT (1.00) | MAPTKDM4ETDP1HTTSMN1; SMN2 | |
| SCHEMBL28748533 | 0.73 | POLB (0.51) | MAPTKDM4ETDP1HTTSMN1; SMN2 | |
| Bromide SCHEMBL5865072 | 0.72 | MAPT (0.97) | MAPTKDM4ETDP1HTTSMN1; SMN2 | |
| SCHEMBL28008057 | 0.71 | METAP2 (0.46) | MAPTKDM4ETDP1HTTSMN1; SMN2 | |
| SCHEMBL6636369 | 0.71 | PRMT5 (0.50) | MAPTKDM4ETDP1HTTSMN1; SMN2 | |
| SCHEMBL30625771 | 0.71 | MMP2 (0.46) | MAPTKDM4ETDP1HTTSMN1; SMN2 | |
| SCHEMBL11069574 | 0.70 | KDM4E (0.46) | MAPTKDM4ETDP1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137586-B | Novel imidazo [4,5-c ] quinoline and imidazo [4,5-c ] [1,5] naphthyridine derivatives as LRRK2 inhibitors | 辉瑞大药厂 | 2021-04-13 | — | — | CN | disclosed |