Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | CCR1 | P32246 | 4/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.47 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.46 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.46 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.46 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GPR6 | P46095 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856793 | 0.82 | KDM4E (0.53) | MAPTCCR1ALDH1A1KDM4ETRPC3 | |
| SCHEMBL2852931 | 0.81 | KDM4E (0.57) | MAPTCCR1ACHEALDH1A1KDM4E | |
| SCHEMBL2855128 | 0.80 | TRPC3 (0.56) | MAPTCCR1ACHEALDH1A1KDM4E | |
| SCHEMBL28696410 | 0.79 | ALDH1A1 (0.76) | MAPTCCR1ACHEALDH1A1KDM4E | |
| SCHEMBL2854612 | 0.79 | CCR1 (0.53) | MAPTCCR1ALDH1A1KDM4ETRPC3 | |
| SCHEMBL2852992 | 0.79 | CCR1 (0.53) | MAPTCCR1ACHEALDH1A1KDM4E | |
| SCHEMBL10365015 | 0.78 | TRPC3 (0.70) | MAPTCCR1ACHEALDH1A1KDM4E | |
| SCHEMBL10365407 | 0.78 | ALDH1A1 (0.70) | MAPTALDH1A1KDM4ESMN1; SMN2POLB | |
| SCHEMBL13513682 | 0.77 | MAPT (0.57) | MAPTCCR1ACHEALDH1A1KDM4E | |
| SCHEMBL4883305 | 0.77 | MAPT (0.57) | MAPTCCR1ACHEALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |