Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 10/20 | 0.40 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.40 |
| ▸ | FLT1 | P17948 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | CLK2 | P49760 | 3/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.40 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.40 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.40 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043643 | 0.81 | DYRK1B (0.46) | DYRK1AAURKAJAK2MAP4K4FGFR1 | |
| SCHEMBL31398027 | 0.76 | DYRK1B (0.42) | DYRK1AAURKAJAK2MAP4K4FGFR1 | |
| SCHEMBL20041453 | 0.74 | YTHDC1 (0.48) | DYRK1AAURKAJAK2MAP4K4FGFR1 | |
| SCHEMBL4042767 | 0.74 | KDM4E (0.48) | DYRK1AAURKAJAK2MAP4K4FGFR1 | |
| SCHEMBL1592867 | 0.73 | DYRK1B (0.44) | DYRK1AAURKAJAK2MAP4K4FGFR1 | |
| SCHEMBL16537120 | 0.73 | MAPK1 (0.40) | DYRK1AAURKAJAK2MAP4K4FGFR1 | |
| SCHEMBL14002611 | 0.73 | KDM4E (0.50) | KDM4EALDH1A1MAPT | |
| SCHEMBL30508312 | 0.71 | DYRK1A (0.55) | DYRK1AAURKAJAK2MAP4K4FGFR1 | |
| SCHEMBL1585071 | 0.71 | DYRK1A (0.55) | DYRK1AAURKAJAK2MAP4K4FGFR1 | |
| SCHEMBL12168140 | 0.70 | ALDH1A1 (0.41) | DYRK1AAURKAJAK2MAP4K4FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112724134-B | Azaindazole bipyridine derivative myeloid cell proliferation inhibitor, preparation method and application thereof in pharmacy | 复旦大学 | 2022-04-01 | — | — | CN | disclosed |
| CN-112724134-A | Azaindazole bipyridine derivative myeloid cell proliferation inhibitor, preparation method and application thereof in pharmacy | 复旦大学 | 2021-04-30 | — | — | CN | disclosed |