SCHEMBL28558455

SCHEMBL28558455

O=C(OC1CCC1)c1ccc([N+](=O)[O-])c(Cc2ccccc2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN1A P35498 1/20 0.44
SCN2A Q99250 1/20 0.44
SCN3A Q9NY46 1/20 0.44
POLB P06746 3/20 0.43
MAPT P10636 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
ALDH1A1 P00352 4/20 0.42
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
KDM4E B2RXH2 1/20 0.42
SMN1; SMN2 Q16637 4/20 0.41
NPBWR1 P48145 1/20 0.41
MCHR1 Q99705 1/20 0.41
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
L3MBTL1 Q9Y468 3/20 0.40
TP53 P04637 1/20 0.40
LMNA P02545 1/20 0.39
HCAR3 P49019 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27714575 0.86 NT5E (0.39) POLBMAPTCYP2C9CYP2C19ALDH1A1
SCHEMBL28718122 0.83 MYC (0.49) POLBMAPTALDH1A1MEN1KMT2A
SCHEMBL29274289 0.82 POLB (0.55) POLBMAPTCYP2C9CYP2C19ALDH1A1
SCHEMBL28635267 0.80 ALDH1A1 (0.46) POLBMAPTCYP2C9CYP2C19ALDH1A1
SCHEMBL11248788 0.78 HCAR3 (0.46) POLBMAPTCYP2C9CYP2C19ALDH1A1
SCHEMBL28636878 0.76 KMT2A (0.42) POLBMAPTALDH1A1MEN1KMT2A
SCHEMBL27879690 0.75 HPGD (0.50) POLBMAPTALDH1A1MEN1KMT2A
SCHEMBL28769504 0.75 THRB (0.37) POLBMAPTCYP2C9CYP2C19MEN1
SCHEMBL7353109 0.74 PDE5A (0.50) POLBMAPTMEN1KMT2ASMN1; SMN2
SCHEMBL27516744 0.72 MEN1 (0.60) POLBMAPTCYP2C9CYP2C19ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112608243-A Synthesis method of trans-3-aminobutanol 深圳市华先医药科技有限公司 2021-04-06 CN disclosed