Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 7/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.33 |
| ▸ | CDK1 | P06493 | 3/20 | 0.33 |
| ▸ | MYT1 | Q01538 | 3/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20596105 | 0.80 | CREBBP (0.34) | CREBBPPRMT5WDR77CDK1MYT1 | |
| SCHEMBL23705926 | 0.78 | DRD2 (0.39) | CREBBPPRMT5WDR77 | |
| SCHEMBL23705880 | 0.76 | CREBBP (0.34) | CREBBPPRMT5WDR77 | |
| SCHEMBL26602775 | 0.75 | PRMT5 (0.35) | CREBBPPRMT5WDR77CDK1MYT1 | |
| SCHEMBL21058305 | 0.74 | CREBBP (0.35) | CREBBPPRMT5WDR77CSNK1DCSNK1E | |
| SCHEMBL31736924 | 0.73 | — | — | |
| SCHEMBL26645670 | 0.73 | PRMT5 (0.41) | CREBBPPRMT5WDR77CSNK1DCSNK1E | |
| SCHEMBL23778976 | 0.72 | ITGB3 (0.32) | CREBBP | |
| SCHEMBL23778965 | 0.70 | DPP4 (0.34) | CDK1MYT1 | |
| SCHEMBL28561720 | 0.69 | TSHR (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109153682-B | Novel pyrazine compounds with oxygen, sulfur and nitrogen linkers for the treatment of infectious diseases | 豪夫迈·罗氏有限公司 | 2021-05-25 | — | — | CN | disclosed |