SCHEMBL28558685

SCHEMBL28558685

C[Si]1(C)CCC(O)C(c2ccccc2)(c2ccccc2)O1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.36
CHRM4 P08173 1/20 0.36
CHRM1 P11229 1/20 0.36
CHRM3 P20309 1/20 0.36
SIGMAR1 Q99720 1/20 0.36
OPRL1 P41146 2/20 0.33
ACHE P22303 1/20 0.33
SLC18A3 Q16572 1/20 0.32
MEN1 O00255 1/20 0.32
RGS12 O14924 1/20 0.32
CYP3A4 P08684 1/20 0.32
KMT2A Q03164 1/20 0.32
MAOB P27338 6/20 0.32
MAOA P21397 3/20 0.32
CHRNB2 P17787 1/20 0.30
SLC6A2 P23975 1/20 0.30
CHRNB4 P30926 1/20 0.30
CHRNA3 P32297 1/20 0.30
CHRNA4 P43681 1/20 0.30
SLC6A3 Q01959 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28577296 0.69 KDM1A (0.41) MAOBMAOA
SCHEMBL245398 0.68 CHRM2 (0.46) CHRM2CHRM4CHRM1CHRM3SIGMAR1
SCHEMBL27762223 0.64 KDM1A (0.43) MAOBMAOA
SCHEMBL182247 0.63 OPRM1 (0.35) OPRL1SLC6A2SLC6A3
SCHEMBL28423950 0.63
SCHEMBL6573456 0.62 TSHR (0.35) OPRL1
SCHEMBL3263252 0.62 HSD11B1 (0.36) OPRL1SLC6A2SLC6A3
Ammonia Solution, Strong SCHEMBL7597471 0.62 OPRM1 (0.34) OPRL1SLC6A2SLC6A3
SCHEMBL2232620 0.62 OPRM1 (0.34) OPRL1MEN1KMT2A
SCHEMBL3365469 0.62 OPRM1 (0.34) OPRL1SLC6A2SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117247673-A Benzenefluoro modified silica gel material and preparation method and application thereof 西安建筑科技大学 2023-12-19 CN disclosed
CN-112831364-B Resin-based composite material water-based release agent and preparation method thereof 烟台大学 2022-07-01 CN disclosed
CN-112831053-B Reactive organosilicon release agent and preparation method thereof 烟台大学 2022-04-29 CN disclosed
CN-112979958-B Mercapto-terminated organic silicon polymer and preparation method thereof 烟台大学 2022-04-26 CN disclosed
CN-112831274-B Hydrosulphonyl-terminated polysiloxane water-based release agent 烟台大学 2022-01-28 CN disclosed
CN-112979958-A Mercapto-terminated organic silicon polymer and preparation method thereof 烟台大学 2021-06-18 CN disclosed
CN-112831053-A Reactive organosilicon release agent and preparation method thereof 烟台大学 2021-05-25 CN disclosed
CN-112831364-A Resin-based composite material water-based release agent and preparation method thereof 烟台大学 2021-05-25 CN disclosed
CN-112831274-A Hydrosulphonyl-terminated polysiloxane water-based release agent 烟台大学 2021-05-25 CN disclosed