Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 2/20 | 0.43 |
| ▸ | CDK8 | P49336 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 3/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.39 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.39 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.39 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22554035 | 0.85 | BMPR1B (0.53) | CCNCCDK8CHEK1ALDH1A1NPC1 | |
| SCHEMBL22553833 | 0.84 | SYK (0.42) | CCNCCDK8CHEK1ALDH1A1NPC1 | |
| SCHEMBL28560413 | 0.82 | SYK (0.45) | CCNCCDK8CHEK1ALDH1A1NPC1 | |
| SCHEMBL28912924 | 0.82 | CYP11B2 (0.45) | CCNCCDK8CHEK1ALDH1A1NPC1 | |
| SCHEMBL28563345 | 0.82 | NPC1 (0.40) | CCNCCDK8ALDH1A1NPC1SYK | |
| SCHEMBL28558370 | 0.82 | NPC1 (0.40) | CCNCCDK8CHEK1ALDH1A1NPC1 | |
| SCHEMBL28557029 | 0.82 | ACVRL1 (0.40) | CCNCCDK8ALDH1A1NPC1SYK | |
| SCHEMBL22553727 | 0.82 | ALDH1A1 (0.48) | CHEK1ALDH1A1NPC1CYP11B2CYP11B1 | |
| SCHEMBL30730791 | 0.82 | ALDH1A1 (0.48) | CHEK1ALDH1A1NPC1CYP11B2CYP11B1 | |
| SCHEMBL28553386 | 0.80 | GAA (0.46) | CCNCCDK8ALDH1A1NPC1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112088157-B | Aryl-bipyridylamine derivatives as phosphatidylinositol phosphokinase inhibitors | 拉文纳制药公司 | 2023-12-26 | — | — | CN | claimed |
| CN-112088157-A | Aryl-bipyridine amine derivatives as phosphoinositide kinase inhibitors | 拉文纳制药公司 | 2020-12-15 | — | — | CN | claimed |
| CN-112088157-B | Aryl-bipyridylamine derivatives as phosphatidylinositol phosphokinase inhibitors | 拉文纳制药公司 | 2023-12-26 | — | — | CN | disclosed |
| CN-112088157-A | Aryl-bipyridine amine derivatives as phosphoinositide kinase inhibitors | 拉文纳制药公司 | 2020-12-15 | — | — | CN | disclosed |