Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16308828 | 1.00 | ACHE (0.39) | ACHETAS1R3TAS1R1TAS1R2HTR1A | |
| SCHEMBL1854099 | 0.89 | ACHE (0.48) | ACHEHTR1ADRD2AADAT | |
| Hydrochloric Acid SCHEMBL5969853 | 0.87 | ACHE (0.50) | ACHEHTR1ADRD2AADAT | |
| SCHEMBL21650396 | 0.79 | KDM4E (0.37) | ACHEIDO1 | |
| SCHEMBL31567653 | 0.79 | TAS1R3 (0.40) | TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL5027056 | 0.79 | TAS1R3 (0.40) | TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL21772217 | 0.78 | PDE7A (0.41) | — | |
| SCHEMBL22061857 | 0.78 | DRD2 (0.46) | ACHETAS1R3TAS1R1TAS1R2DRD2 | |
| SCHEMBL12507111 | 0.78 | TAS1R3 (0.39) | TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL19667607 | 0.78 | DRD2 (0.46) | ACHEDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654247-B1 | ALKYNYL ARYL CARBOXAMIDES | MERCK SERONO SA (CH) | 2010-01-20 | — | — | EP | disclosed |
| US-7589232-B2 | Alkynyl aryl carboxamides | LABORATORIES SERONO S.A. (CH) | 2009-09-15 | — | — | US | disclosed |
| US-20070105913-A1 | Alkynyl aryl carboxamides | APPLIED RESEARCH SYSTEMS ARS HOLDINGS N.V. (NL) | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105913-A1 | Alkynyl aryl carboxamides | ECHS1, IRS1, HCCS | ACHE 4290/4885TAS1R3 1785/4885TAS1R1 1616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.