Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GPR6 | P46095 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850404 | 0.85 | KMT2A (0.52) | SMN1; SMN2MAPK14MAPTPOLBLMNA | |
| SCHEMBL2860252 | 0.83 | MAPT (0.39) | SMN1; SMN2MAPK14MAPTPOLBTRPC3 | |
| SCHEMBL2857034 | 0.81 | KDM4E (0.62) | KDM4EALDH1A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL2852163 | 0.80 | KMT2A (0.53) | KDM4EALDH1A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL2852931 | 0.80 | KDM4E (0.57) | KDM4EALDH1A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL28696410 | 0.80 | ALDH1A1 (0.76) | KDM4EALDH1A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL2855512 | 0.80 | MALT1 (0.55) | KDM4EALDH1A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL13513708 | 0.78 | KDM4E (0.53) | KDM4EALDH1A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL2852818 | 0.78 | NPC1 (0.50) | KDM4EALDH1A1MAPTMALT1 | |
| SCHEMBL2856075 | 0.77 | NAMPT (0.56) | KDM4EALDH1A1SMN1; SMN2MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |