Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 1/20 | 0.49 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.49 |
| ▸ | CCR1 | P32246 | 12/20 | 0.48 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.42 |
| ▸ | JUN | P05412 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2855376 | 0.91 | CCR1 (0.60) | CCR1 | |
| SCHEMBL2848180 | 0.87 | CCR1 (0.51) | CCR1TRPC3 | |
| SCHEMBL2855591 | 0.84 | CCR2 (0.41) | P2RX1TMPRSS4CCR1CCR2TACR1 | |
| SCHEMBL2855565 | 0.82 | CCR1 (0.66) | P2RX1TMPRSS4CCR1TRPC3 | |
| SCHEMBL2857071 | 0.81 | CCR1 (0.57) | P2RX1TMPRSS4CCR1TACR1MLYCD | |
| SCHEMBL2854060 | 0.80 | KDM4E (0.65) | CCR1TACR1 | |
| SCHEMBL2857075 | 0.80 | P2RX1 (0.57) | P2RX1TMPRSS4CCR1TACR1MLYCD | |
| SCHEMBL2852810 | 0.80 | KDM4E (0.48) | — | |
| SCHEMBL2854820 | 0.80 | MAPK14 (0.47) | CCR1TRPC3 | |
| SCHEMBL2857923 | 0.79 | CCR1 (0.66) | CCR1TRPC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |